Professor Onishi Motoko from the Department of Applied Biochemistry, Department of Applied Biology, Chubu University, Japan, and others cooperated with San-ei Sucrochemical, a saccharified product company that produces glucose and other saccharification products, and found through human clinical trials that indigestible oligosaccharides possess both sugar and acid properties. "Maltobionic acid" inhibits the loss of collagen components in bones and helps maintain bone components.
About five years ago, the research team looked at the "maltonic acid" contained in honey, which people have been eating since ancient times, and evaluated its effect on maintaining bone health. In the evaluation experiment, the research team first performed cell experiments using bone marrow cells collected from mouse femurs and found that adding maltonic acid to the cells inhibited osteoclast differentiation. Then, animal experiments were conducted, and after feeding the ovariectomized postmenopausal model mice with a diet containing maltonic acid for 80 consecutive days, it was confirmed that calcium loss and bone density in the femur were significantly suppressed compared with mice fed a diet without maltonic acid. decline.
In order to verify the effect on the human body, a human clinical trial was also carried out, in which female employees in their 40s to 60s of Chubu University ingested 4 g of granules containing maltonic acid per day for 4 consecutive weeks. The results showed that the excretion of bone-derived collagen components (DPD, u-NTx, indicators of bone resorption) in the urine of 33 menopausal men for more than 1 year was significantly reduced compared with that before the intake of maltonic acid. , sustained intake of maltonic acid inhibited bone loss. In addition, maltonic acid is an indigestible oligosaccharide, so this clinical trial confirmed that maltonic acid also has the effect of improving laxatives and regulating the gastrointestinal state.
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